Search results for "Barnes maze"
showing 4 items of 4 documents
Statistical analysis of latency outcomes in behavioral experiments
2011
In experimental designs of animal models, memory is often assessed by the time for a performance measure to occur (latency). Depending on the cognitive test, this may be the time it takes an animal to escape to a hidden platform (water maze), an escape tunnel (Barnes maze) or to enter a dark component (passive avoidance test). Latency outcomes are usually statistically analyzed using ANOVAs. Besides strong distributional assumptions, ANOVA cannot properly deal with animals not showing the performance measure within the trial time, potentially causing biased and misleading results. We propose an alternative approach for statistical analyses of latency outcomes. These analyses have less distr…
Spatial learning and long-term memory impairments in RasGrf1 KO, Pttg1 KO, and double KO mice
2018
© 2018 The Authors.
Assessment of postischemic neurogenesis in rats with cerebral ischemia and propofol anesthesia.
2009
Background Postischemic endogenous neurogenesis can be dose-dependently modulated by volatile anesthetics. The intravenous anesthetic propofol is used during operations with a risk of cerebral ischemia, such as neurosurgery, cardiac surgery, and vascular surgery. The effects of propofol on neurogenesis are unknown and, therefore, the object of this study. Methods Eighty male Sprague-Dawley rats were randomly assigned to treatment groups with propofol administration for 3 h: 36 mg x kg(-1) x h(-1) propofol with or without cerebral ischemia and 72 mg x kg(-1) x h(-1) propofol with or without cerebral ischemia. In addition, 7 rats with propofol administration for 6 h and 14 treatment-naive ra…
Exposure to N-ethyl-N-nitrosourea in adult mice alters structural and functional integrity of neurogenic sites.
2011
BackgroundPrevious studies have shown that prenatal exposure to the mutagen N-ethyl-N-nitrosourea (ENU), a N-nitroso compound (NOC) found in the environment, disrupts developmental neurogenesis and alters memory formation. Previously, we showed that postnatal ENU treatment induced lasting deficits in proliferation of neural progenitors in the subventricular zone (SVZ), the main neurogenic region in the adult mouse brain. The present study is aimed to examine, in mice exposed to ENU, both the structural features of adult neurogenic sites, incorporating the dentate gyrus (DG), and the behavioral performance in tasks sensitive to manipulations of adult neurogenesis.Methodology/principal findin…